منابع مشابه
T-cell prolymphocytic leukemia (T-PLL)
Few cases have been reported in the literature. So far; karyotypes are usually complex. 14q11 abnormalities: very frequent, either as an inv(14)(q11q32) or as a translocation t(14;14)(q11;q32); another reported change involving 14q11 is a translocation t(X;14)(q28;q11), similar to the translocation observed in ataxia-telangectasia, involving the Mature T-cell Prolymphocyte 1 (MTCP1) gene locate...
متن کاملAccumulation of T-cell with Extremely Short Telomeres in T-cell Prolymphocytic Leukemia (t-pll)
in MFI values, however it was not statisticlly significant. The mean percentage of CD19/TNF-α cells was significantly higher, while the percentage of CD19/IL-2, CD19/IL-4 and CD19/ IFN-γ was lower in ZAP-70 positive than ZAP-70 negative patients. There was no significant difference between ZAP-70 positive and ZAP-70 negative group as far as MFI was concerned. Conclusions. Our findings demonstra...
متن کاملT-cell Prolymphocytic Leukemia.
BACKGROUND: T-cell prolymphocytic leukemia (T-PLL) is a post-thymic T-cell malignancy with aggressive clinical course. Although T-PLL has been referred to under different designations, it is a distinct clinico-biological entity and should be distinguished from other T-cell disorders. METHODS: The literature on T-PLL is reviewed. Experience on the clinical and laboratory features, differential d...
متن کاملT-cell prolymphocytic leukemia.
T-cell prolymphocytic leukemia is a rare and unusual malignancy characterized by the proliferation of small- to medium-sized prolymphocytes of postthymic origin with distinctive clinical, morphologic, immunophenotypic, and cytogenetic features. Involvement of the peripheral blood, bone marrow, lymph nodes, liver, spleen, and skin can occur. The clinical course is typically very aggressive with ...
متن کاملCytogenetic studies on prolymphocytic leukemia. II. T cell prolymphocytic leukemia.
We report chromosome abnormalities in 15 cases of T cell prolymphocytic leukemia (T-PLL). All cases were characterized by clinical, morphological, and membrane marker analysis. The most frequent abnormality was an inv(14)(q11q32) observed in nine cases. The T cell receptor (TCR) alpha chain gene is localized to 14q11 and the immunoglobulin heavy-chain gene to region 14q32. Four cases also had t...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2010
ISSN: 1768-3262
DOI: 10.4267/2042/32064